FARMACOLOGIA E TOSSICOLOGIA – Dottorato di Ricerca in Medicina Sperimentale DMS

Pubblicazioni più recenti

Busceti CL, Di Menna L, Castaldi S, D’Errico G, Taddeucci A, Bruno V, Fornai F, Pittaluga A, Battaglia G, Nicoletti F.

Adaptive changes in group-II metabotropic glutamate receptors underlie the deficit in recognition memory induced by methamphetamine in mice.
eNeuro. 2024 Jul 5:ENEURO.0523-23.2024. doi: 10.1523/ENEURO.0523-23.2024.

Raiteri L.

Interactions Involving Glycine and Other Amino Acid Neurotransmitters: Focus on Transporter-Mediated Regulation of Release and Glycine–Glutamate Crosstalk

Biomedicines 2024, 12(7), 1518; https://doi.org/10.3390/biomedicines12071518

Olivero G, Taddeucci A, Vallarino G, Trebesova H, Roggeri A, Gagliani MC, Cortese K, Grilli M, Pittaluga A.

Complement tunes glutamate release and supports synaptic impairments in an animal model of multiple sclerosis.
Br J Pharmacol. 2024 Jun;181(12):1812-1828. doi: 10.1111/bph.16328.

Schepers M, Hendrix S, Mussen F, van Breedam E, Ponsaerts P, Lemmens S, Hellings N, Ricciarelli R, Fedele E, Bruno O, Brullo C, Prickaerts J, Van Broeckhoven J, Vanmierlo T.

Amelioration of functional and histopathological consequences after spinal cord injury through phosphodiesterase 4D (PDE4D) inhibition.

Neurotherapeutics. 2024 May 16;21(4):e00372. doi: 10.1016/j.neurot.2024.e00372.

Valenza M, Facchinetti R, Torazza C, Ciarla C, Bronzuoli MR, Balbi M, Bonanno G, Popoli M, Steardo L, Milanese M, Musazzi L, Bonifacino T, Scuderi C.

Molecular signatures of astrocytes and microglia maladaptive responses to acute stress are rescued by a single administration of ketamine in a rodent model of PTSD.

Transl Psychiatry. 2024 May 25;14(1):209. doi: 10.1038/s41398-024-02928-6.

Raffaele S, Nguyen N, Milanese M, Mannella FC, Boccazzi M, Frumento G, Bonanno G, Abbracchio MP, Bonifacino T, Fumagalli M.

Montelukast improves disease outcome in SOD1G93A female mice by counteracting oligodendrocyte dysfunction and aberrant glial reactivity

Br J Pharmacol. 2024 May 15. doi: 10.1111/bph.16408. Online ahead of print.

Bacchetti F, Schito AM, Milanese M, Castellaro S, Alfei S.

Anti Gram-Positive Bacteria Activity of Synthetic Quaternary Ammonium Lipid and Its Precursor Phosphonium Salt

Int J Mol Sci. 2024 Feb 27;25(5):2761. doi: 10.3390/ijms25052761.

Mingardi J, Ndoj E, Bonifacino T, Misztak P, Bertoli M, La Via L, Torazza C, Russo I, Milanese M, Bonanno G, Popoli M, Barbon A, Musazzi L.
Functional and Molecular Changes in the Prefrontal Cortex of the Chronic Mild Stress Rat Model of Depression and Modulation by Acute Ketamine.
Int J Mol Sci. 2023 Jun 28;24(13):10814. doi: 10.3390/ijms241310814.

Bonifacino T, Mingardi J, Facchinetti R, Sala N, Frumento G, Ndoj E, Valenza M, Paoli C, Ieraci A, Torazza C, Balbi M, Guerinoni M, Muhammad N, Russo I, Milanese M, Scuderi C, Barbon A, Steardo L, Bonanno G, Popoli M, Musazzi L.
Changes at glutamate tripartite synapses in the prefrontal cortex of a new animal model of resilience/vulnerability to acute stress.
Transl Psychiatry. 2023 Feb 18;13(1):62. doi: 10.1038/s41398-023-02366-w.

Cervetto C, Pistollato F, Amato S, Mendoza-de Gyves E, Bal-Price A, Maura G, Marcoli M.
Assessment of neurotransmitter release in human iPSC-derived neuronal/glial cells: a missing in vitro assay for regulatory developmental neurotoxicity testing.
Reprod Toxicol. 2023 Apr;117:108358. doi: 10.1016/j.reprotox.2023.108358. Epub 2023 Mar 1.

Amato S, Averna M, Guidolin D, Ceccoli C, Gatta E, Candiani S, Pedrazzi M, Capraro M, Maura G, Agnati LF, Cervetto C, Marcoli M.
Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes.
Int J Mol Sci. 2023 Feb 28;24(5):4677. doi: 10.3390/ijms24054677.

Fedele E.

Anti-Amyloid Therapies for Alzheimer’s Disease and the Amyloid Cascade Hypothesis.
Int J Mol Sci. 2023 Sep 24;24(19):14499. doi: 10.3390/ijms241914499.

Schepers M, Paes D, Tiane A, Rombaut B, Piccart E, van Veggel L, Gervois P, Wolfs E, Lambrichts I, Brullo C, Bruno O, Fedele E, Ricciarelli R, Ffrench-Constant C, Bechler ME, van Schaik P, Baron W, Lefevere E, Wasner K, Grünewald A, Verfaillie C, Baeten P, Broux B, Wieringa P, Hellings N, Prickaerts J, Vanmierlo T.
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.

Brain Behav Immun. 2023 Mar;109:1-22. doi: 10.1016/j.bbi.2022.12.020.

Torazza C, Provenzano F, Gallia E, Cerminara M, Balbi M, Bonifacino T, Tessitore S, Ravera S, Usai C, Musante I, Puliti A, Van Den Bosch L, Jafar-Nejad P, Rigo F, Milanese M*,Bonanno G.
Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes.
Cells. 2023 Jul 27;12(15):1952. doi: 10.3390/cells12151952.

Forti L, Ndoj E, Mingardi J, Secchi E, Bonifacino T, Schiavon E, Carini G, La Via L, Russo I, Milanese M, Gennarelli M, Bonanno G, Popoli M, Barbon A, Musazzi L.
Dopamine-Dependent Ketamine Modulation of Glutamatergic Synaptic Plasticity in the Prelimbic Cortex of Adult Rats Exposed to Acute Stress.
Int J Mol Sci. 2023 May 13;24(10):8718. doi: 10.3390/ijms24108718.

Olivero G, Grilli M, Marchi M, Pittaluga A.

Metamodulation of presynaptic NMDA receptors: New perspectives for pharmacological interventions.
Neuropharmacology. 2023 Aug 15;234:109570. doi: 10.1016/j.neuropharm.2023.109570.

Roggeri A, Olivero G, Usai C, Vanmierlo T, Pittaluga A.
Presynaptic Release-Regulating Sphingosine 1-Phosphate 1/3 Receptors in Cortical Glutamatergic Terminals: Adaptations in EAE Mice and Impact of Therapeutic FTY720.
Cells. 2023 Sep 24;12(19):2343. doi: 10.3390/cells12192343.

Iovino L, Giusti V, Pischedda F, Giusto E, Plotegher N, Marte A, Battisti I, Di Iacovo A, Marku A, Piccoli G, Bandopadhyay R, Perego C, Bonifacino T, Bonanno G, Roseti C, Bossi E, Arrigoni G, Bubacco L, Greggio E, Hilfiker S, Civiero L.
Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease.
Acta Neuropathol. 2022 Jul;144(1):81-106. doi: 10.1007/s00401-022-02437-0.

Bonifacino T, Micheli L, Torazza C, Ghelardini C, Farina C, Bonanno G, Milanese M, Di Cesare Mannelli L, Scherz MW.

Pharmacological Profile of MP-101, a Novel Non-racemic Mixture of R- and S-dimiracetam with Increased Potency in Rat Models of Cognition, Depression and Neuropathic Pain.

Cells. 2022 Dec 13;11(24):4027. doi: 10.3390/cells11244027.

Amato S, Averna M, Guidolin D, Pedrazzi M, Pelassa S, Capraro M, Passalacqua M, Bozzo M, Gatta E, Anderlini D, Maura G, Agnati LF, Cervetto C, Marcoli M.
Heterodimer of A2A and Oxytocin Receptors Regulating Glutamate Release in Adult Striatal Astrocytes.
Int J Mol Sci. 2022 Feb 19;23(4):2326. doi: 10.3390/ijms23042326.

Marcoli M, Cervetto C, Amato S, Fiorucci C, Maura G, Mariottini P, Cervelli M.
Transgenic Mouse Overexpressing Spermine Oxidase in Cerebrocortical Neurons: Astrocyte Dysfunction and Susceptibility to Epileptic Seizures.
Biomolecules. 2022 Jan 25;12(2):204. doi: 10.3390/biom12020204.

Villa V, Montalto G, Caudano F, Fedele E, Ricciarelli R.

Selective inhibition of phosphodiesterase 4D increases tau phosphorylation at Ser214 residue.
Biofactors. 2022 Sep;48(5):1111-1117. doi: 10.1002/biof.1847.

Sala N, Paoli C, Bonifacino T, Mingardi J, Schiavon E, La Via L, Milanese M , Tornese P, Datusalia AK, Rosa J, Facchinetti R, Frumento G, Carini G, Salerno Scarzella F, Scuderi C, Forti L, Barbon A, Bonanno G, Popoli M, Musazzi L.
Acute Ketamine Facilitates Fear Memory Extinction in a Rat Model of PTSD Along With Restoring Glutamatergic Alterations and Dendritic Atrophy in the Prefrontal Cortex.
Front Pharmacol. 2022 Mar 17;13:759626. doi: 10.3389/fphar.2022.759626. eCollection 2022.

Provenzano F, Nyberg S, Giunti D, Torazza C, Parodi B, Bonifacino T, Usai C, Kerlero de Rosbo N, Milanese M*, Uccelli A, Shaw PJ, Ferraiuolo L, Bonanno G.

Micro-RNAs Shuttled by Extracellular Vesicles Secreted from Mesenchymal Stem Cells Dampen Astrocyte Pathological Activation and Support Neuroprotection in In-Vitro Models of ALS.
Cells. 2022 Dec 4;11(23):3923. doi: 10.3390/cells11233923.

Fagiani F, Baronchelli E, Pittaluga A, Pedrini E, Scacchi C, Govoni S, Lanni C.

The Circadian Molecular Machinery in CNS Cells: A Fine Tuner of Neuronal and Glial Activity With Space/Time Resolution.
Front Mol Neurosci. 2022 Jul 1;15:937174. doi: 10.3389/fnmol.2022.937174.

Taddeucci A, Olivero G, Roggeri A, Milanese C, Giorgio FPD, Grilli M, Marchi M, Garrone B, Pittaluga A.
Presynaptic 5-HT_2A-mGlu2/3 Receptor-Receptor Crosstalk in the Prefrontal Cortex: Metamodulation of Glutamate Exocytosis.
Cells. 2022 Sep 28;11(19):3035. doi: 10.3390/cells11193035.